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If you are allergic to any of Zyrtec-D's ingredients, to the similar drug Atarax, or to certain drugs that tend to raise blood pressure (adrenergic agents), do not take Zyrtec-D. Symptoms that indicate a sensitivity to adrenergic agents include insomnia, dizziness, weakness, tremor, or irregular heartbeat.

You should also avoid Zyrtec-D if you have severe high blood pressure, severe heart disease, high pressure in the eye (glaucoma), or difficulty urinating. Never combine Zyrtec-D with a drug classified as an MAO inhibitor, such as the antidepressants Nardil and Parnate.

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