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• Serious allergic reactions including swelling of the face, lips, tongue, and/or throat which may cause difficulty breathing or swallowing, hives, wheezing, or shock (loss of blood pressure and consciousness) can occur. These may require treatment right away. Severe skin reactions have also been reported.
• Serious stomach problems, such as stomach and intestinal bleeding, can occur with or without warning symptoms. These problems, if severe, could lead to hospitalization or death. Although this happens rarely, you should watch for signs (for instance, stomach burning, vomiting blood, or if there is blood in your bowel movement or it is black and sticky like tar) that you may have this serious side effect and tell your doctor right away.
• Heart attacks and other serious events, such as blood clots in your body, have been reported in patients taking Vioxx.
• Serious kidney problems can occur, including acute (sudden) kidney failure and worsening of chronic kidney failure.
• Severe liver problems, including hepatitis, jaundice and liver failure, can occur in patients taking NSAIDs, including Vioxx. Tell your doctor if you develop symptoms of liver problems. These include nausea, tiredness, itching, pain in the right upper abdomen, yellow skin or eyes, and flu-like symptoms.

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