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Synthroid side effects, other than those indicative of thyrotoxicosis as a result of therapeutic overdosage, either initially or during the maintenance periods, are rare.

However, the following has been known to occur:

• Craniosynostosis has been associated with iatrogenic hyperthyroidism in infants receiving thyroid hormone replacement therapy.
• Inadequate doses of levothyroxine sodium may produce or fail to resolve symptoms of hypothyroidism.
• Hypersensitivity reactions to the product excipients, such as rash and urticaria, may occur.
• Partial hair loss may occur during the initial months of therapy, but is generally transient. The incidence of continued hair loss is unknown.
• Pseudotumor cerebri has been reported in pediatric patients receiving thyroid hormone replacement therapy.

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