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Wellbutrin SR (Bupropion Sustained Release Tablets) Manufactured by: Glaxo Smith Kline This product requires a valid prescription

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Wellbutrin SR (Bupropion) belongs to the family of medications known as antidepressants. Wellbutrin SR (Bupropion) is used for the treatment of depression (Wellbutrin SR) and as an aid for quitting smoking (Zyban). It works by affecting the balance of chemicals that occur naturally in the brain.

For the treatment of depression, the full effects of the medication may not be seen until after several weeks of treatment.

Your doctor may have suggested Wellbutrin SR (Bupropion) for conditions other than the ones listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Wellbutrin SR (Bupropion), speak to your doctor. Do not stop taking Wellbutrin SR (Bupropion)without consulting your doctor.

Do not give Wellbutrin SR (Bupropion) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Wellbutrin SR (Bupropion) if their doctor has not prescribed it.

The recommended dose of Wellbutrin SR (Bupropion) for treatment of depression is 100 mg to 300 mg per day. Daily doses over 150 mg are divided into two doses. Do not exceed the maximum dose of 300 mg per day, and do not take a single dose greater than 150 mg. People with reduced liver or kidney function may require a lower dose.

Multiple Wellbutrin SR (Bupropion) daily doses should be taken at least eight hours apart. Wellbutrin SR (Bupropion) is very important that Wellbutrin SR (Bupropion) tablets be swallowed whole.

Many things can affect the dose of Wellbutrin SR (Bupropion) that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is very important that Wellbutrin SR (Bupropion) be taken on a regular schedule as prescribed by the doctor. If you miss a dose of Wellbutrin SR (Bupropion) take it as soon as you remember it. If Wellbutrin SR (Bupropion) is within eight hours of your next dose, skip the missed dose and carry on with your regular schedule. Do not take a double dose to make up for a missed one.

Wellbutrin SR (Bupropion) should not be taken by anyone who:

-is taking another medication that contains bupropion (e.g., Zyban or Wellbutrin SR)
-has a seizure disorder
-has or has had an eating disorder (bulimia or anorexia nervosa)
-has taken a monoamine oxidase inhibitor (MAO inhibitor; e.g., phenelzine, tranylcypromine) within the past two weeks
-is currently taking thioridazine (an antipsychotic drug)
-is having abrupt withdrawal from alcohol or sedatives
-is allergic to bupropion or to any of the ingredients of this medication

Wellbutrin SR Side Effects:

The Wellbutrin SR (Bupropion) side effects listed below are not experienced by everyone who takes Wellbutrin SR (Bupropion). If you are concerned about Wellbutrin SR (Bupropion) side effects, discuss the risks and benefits of this medication with your doctor.

The following Wellbutrin SR (Bupropion) side effects may go away as your body becomes used to the medicine; check with your doctor if they continue or become bothersome.

More common side effects of Wellbutrin SR:
abdominal pain
constipation
decrease in appetite
dizziness
dryness of mouth
increased sweating
nausea or vomiting
trembling or shaking
trouble sleeping
weight loss (unusual)
Less common
blurred vision
change in sense of taste
drowsiness
feeling of fast or irregular heartbeat
frequent need to urinate
muscle pain
sore throat
unusual feeling of well-being
Check with your doctor as soon as possible if any of the following side effects occur:

More common side effects of Wellbutrin SR:
agitation
anxiety
Less common
buzzing or ringing in ears
headache (severe)
skin rash, hives, or itching
Rare
confusion
extreme distrust
fainting
false beliefs that cannot be changed by facts
hallucinations
seizures (convulsions), especially with higher doses
trouble concentrating
Symptoms of overdose
fast heartbeat
hallucinations
loss of consciousness
nausea
seizures
vomiting

Identical medications: Wellbutrin SR and Zyban contain the same active ingredient (bupropion). Anyone taking one of these medications should not take the other or any other product containing bupropion, as the risk of seizures increases with an increased dosage.

Heart disease: There is no experience establishing the safety of bupropion for use by people with a recent history of heart attack or unstable heart disease.

Liver disease: Because bupropion is cleared from the body through both the liver and the kidney, caution and lower doses should be used by people with liver disease or kidney disease. Bupropion is not recommended for use by people with severe liver disease unless the benefits outweigh the risks.

Suicidal or agitated behaviour: Adults and children taking Wellbutrin SR (Bupropion) may feel agitated (restless, anxious, aggressive, emotional, and feeling not like themselves), or they may want to hurt themselves or others. These symptoms may occur within several weeks after people start taking this medication. People should be closely monitored by their doctor for emotional and behavioural changes.

Stopping Wellbutrin SR (Bupropion): Stopping Wellbutrin SR (Bupropion)suddenly may lead to side effects. If you are thinking of stopping Wellbutrin SR (Bupropion), check with your doctor first.

Drowsiness/reduced alertness: People taking Wellbutrin SR (Bupropion) should avoid operating hazardous machinery, including cars, until they are certain that the medication does not impair their mental alertness, judgment, or physical coordination.

Seizure risk: Wellbutrin SR (Bupropion)should be used with extreme caution by people who are at increased risk of seizures. Things which increase the risk of seizures include:

abrupt withdrawal from alcohol, benzodiazepines, or other sedatives
addiction to cocaine, stimulants, or opiates (such as morphine)
diabetes treated with oral medications or insulin
excessive alcohol use
history of head trauma or seizures (including epilepsy)
tumours of the the brain or spinal cord
use of other medications that make seizures more likely (e.g., antipsychotics, antidepressants, lithium, theophylline, steroids)
use of over-the-counter stimulants or appetite suppressants
Pregnancy: The safety of bupropion during pregnancy has not been established. It has been reported that babies born to pregnant women who have taken medications of this kind during the last trimester of pregnancy may be adversely affected. Physicians and pregnant women should carefully consider the benefits and the risks of all treatment options.

Wellbutrin SR (Bupropion) Breast-feeding: Wellbutrin SR (Bupropion) passes into breast milk. Because this medication presents risks to nursing infants, a decision should be made whether to discontinue breast-feeding or to discontinue bupropion, taking into account the importance of the medication to the mother.

Wellbutrin SR (Bupropion) Children: The safety and effectiveness of Wellbutrin SR (Bupropion) for use by children and adolescents under 18 years old have not been established. The use of Wellbutrin SR (Bupropion) in children below the age of 18 may cause behavioural and emotional changes, such as suicidal thoughts and behaviour.

The following medications may affect how Wellbutrin SR (Bupropion) works or increase the risk of side effects:

carbamazepine
corticosteroids (e.g., prednisone)
cyclophosphamide
guanfacine
levodopa
lithium
monoamine oxidase inhibitors (MAO inhibitors; e.g., phenelzine, tranylcypromine, moclobemide) - bupropion should not be started until at least 14 days after MAO inhibitors are stopped
orphenadrine
phenytoin
phenobarbital
ritonavir
theophylline

The following medications may be affected by Wellbutrin SR (Bupropion):

antipsychotics (e.g., haloperidol, risperidone, thioridazine)
beta-blockers (e.g., metoprolol)
flecainide
levodopa
propafenone
SSRIs (e.g., paroxetine, sertraline, fluoxetine)
tricyclic antidepressants (e.g., nortriptyline, imipramine, desipramine)
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

-stop taking one of the medications
-change one of the medications to another,
-change how you are taking one or both of the medications, or
-leave everything as is.

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