Vioxx (rofecoxib)

Rofecoxib belongs to the family of medications known as nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs work by blocking a response to injury in the body that leads to inflammation and pain. Rofecoxib is used for the treatment of osteoarthritis and rheumatoid arthritis, for the relief of pain in adults, and for the treatment of painful menstruation. It helps with these conditions by relieving pain and reducing swelling and inflammation.

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Rofecoxib

Rofecoxib is a white to off- white to light yellow powder. It is sparingly soluble in acetone, slightly soluble in methanol and isopropyl acetate, very slightly soluble in ethanol, practically insoluble in octanol, and insoluble in water. The empirical formula for rofecoxib is C 17 H 14 O 4 S, and the molecular weight is 314.36. Each tablet of VIOXX for oral administration contains either 12.5, 25 or 50 mg of rofecoxib and the following inactive ingredients: croscarmellose sodium, hydroxypropyl cellulose, lactose, magnesium stearate, microcrystalline cellulose, and yellow ferric oxide.

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Canadian Vioxx

Vioxx is available in tablet and suspension form.

Tablets:
12.5 mg: Each cream-to-off-white coloured, round, shallow-cup tablet, engraved "MRK 74" on one side and "VIOXX" on the other, contains rofecoxib 12.5 mg.
25 mg: Each yellow, round tablet, engraved "MRK 110" on one side and "VIOXX" on the other, contains rofecoxib 25 mg.
Nonmedicinal ingredients: croscarmellose sodium, hydroxypropyl cellulose, lactose, magnesium stearate, microcrystalline cellulose, and yellow ferric oxide.

Suspension: Each 5 mL of opaque, white-to-faint-yellow suspension with strawberry flavour contains rofecoxib 12.5 mg. Nonmedicinal ingredients: citric acid (monohydrate), purified water, sodium citrate (dihydrate), sodium methylparaben (preservative), sodium propylparaben (preservative), sorbitol solution, strawberry flavour, and xanthan gum. Store at room temperature and protect from freezing. Shake well before using.

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Vioxx Side Effects

Vioxx (rofecoxib) is usually very well tolerated. The most common side effects of Vioxx were:

  • back pain
  • blurred vision
  • constipation
  • diarrhea
  • dizziness
  • headache
  • loss of energy or weakness
  • nausea
  • stuffy or runny nose

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Vioxx Precautions

Rofecoxib should not be used by anyone who:

  • is allergic to rofecoxib or any ingredient of the medication
  • has experienced any of the following after taking ASA or other NSAIDs (nonsteroidal anti-inflammatory drugs, e.g., naproxen, ibuprofen, indomethacin):
    • asthma
    • hives
    • allergic-type reactions
  • has an active peptic (stomach) ulcer, bleeding from the stomach or intestines, or active inflammatory disease of the bowel
  • has severely impaired liver function or active liver disease
  • has severely impaired kidney function or kidney disease that is getting worse

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Vioxx Manufacturer

No information is available about the manufacturer of Vioxx at this time.

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