Risperdal (risperidone)
Rispderdal (risperidone) belongs to group of medications known as antipsychotic agents. Other members of this group of drugs include olanzapine and quetiapine. Risperdone is used to treat mental and emotional problems such as schizophrenia. Schizophrenia can cause symptoms such as hallucinations (e.g., hearing, seeing, or sensing things that are not there), delusions, unusual suspiciousness, and emotional withdrawal. People with this condition may also feel depressed, anxious or tense.
Risperdal is also used for the short-term treatment of behavior problems, such as verbal or physical aggression and suspiciousness and agitation, in people with severe dementia. Medicines like Risperdal are thought to work by correcting the function of nerve pathways in certain areas of the brain.
Risperidone
Risperidone is a psychotropic agent belonging to the chemical class of benzisoxazole derivatives. Risperidone is a white to slightly beige powder. It is practically insoluble in water, freely soluble in methylene chloride, and soluble in methanol and 0.1 N HCl. RISPERDAL ® tablets are available in 0.25 mg (dark yellow), 0.5 mg (red-brown), 1 mg (white), 2 mg (orange), 3 mg (yellow), and 4 mg (green) strengths. Inactive ingredients are colloidal silicon dioxide, hydroxypropyl methylcellulose, lactose, magnesium stearate, microcrystalline cellulose, propylene glycol, sodium lauryl sulfate, and starch (corn). Tablets of 0.25, 0.5, 2, 3, and 4 mg also contain talc and titanium dioxide. The 0.25 mg tablets contain yellow iron oxide; the 0.5 mg tablets contain red iron oxide; the 2 mg tablets contain FD&C Yellow No. 6 Aluminum Lake; the 3 mg and 4 mg tablets contain D&C Yellow No. 10; the 4 mg tablets contain FD&C Blue No. 2 Aluminum Lake.
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Canadian Risperdal
Risperdal is supplied as tablets and an oral solution.
The tablets are oblong-shaped and available as 0.25 mg (yellow), 0.5 mg (brownish-red), 1 mg (white), 2 mg (orange), 3 mg (yellow), and 4 mg (green). Non-medicinal ingredients in the 1.0 mg tablets include colloidal anhydrous silica, hypromellose, lactose, magnesium stearate, maize starch, microcrystalline cellulose, propylene glycol, and sodium lauryl sulfate. The 0.5 mg tablets contain the same ingredients as the 1.0 mg tablets plus talc and titanium dioxide. The 0.25 mg tablets contain the same ingredients as the 1.0 mg tablets plus talc, titanium dioxide, and yellow ferric oxide. The 2.0 mg tablets contain the same ingredients as the 1.0 mg tablets plus talc, titanium dioxide, and sunset yellow aluminium lake. The 3.0 mg and 4.0 mg tablets contain the same ingredients as the 1.0 mg tablets plus talc, titanium dioxide, and quinoline yellow.
The oral solution contains 1 mg/mL risperidone. Non-medicinal ingredients include benzoic acid, purified water, sodium hydroxide, and tartaric acid.
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Risperdal Side Effects
Risperdal (risperidone) is usually very well tolerated. The most common side effects of Risperdal were:
- sleepiness
- tremors, decreased motor function or activity
- a feeling of restlessness
- swelling of the ankles
- stuffed nose
- dizziness, lightheadedness
- difficulty breathing
- increased heart rate
- sleeplessness/sleepiness
- anxiety
- tremors, decreased motor function or activity
- a feeling of restlessness
- dizziness
- stuffed nose
- constipation
- weight gain (average 2.3 kg)
- increased heart rate
Risperdal Precautions
Neuroleptic Malignant Syndrome (NMS)
A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant Syndrome (NMS) has been reported in association with Rispderdal. Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status, and evidence of autonomic instability (irregular pulse or blood pressure, tachycardia, diaphoresis, and cardiac dysrhythmia). Additional signs may include elevated creatine phosphokinase, myoglobinuria (rhabdomyolysis), and acute renal failure. The diagnostic evaluation of patients with this syndrome is complicated. In arriving at a diagnosis, it is important to identify cases in which the clinical presentation includes both serious medical illness (e.g., pneumonia, systemic infection, etc.) and untreated or inadequately treated extrapyramidal signs and symptoms (EPS). Other important considerations in the differential diagnosis include central anticholinergic toxicity, heat stroke, drug fever, and primary central nervous system pathology.
Risperdal Manufacturer
No information is available about the manufacturer of Risperdal at this time.
