Plavix (clopidogrel)

Plavix (Clopidogrel) is used to help prevent heart attacks, strokes, and other circulation problems for people who have atherosclerosis (narrowed blood vessels caused by "hardening of the arteries") and who have already experienced at least one blood clotting event (such as heart attack or stroke), or for people with acute coronary syndromes. Normally, platelets help the blood to clot when needed, such as after an injury. When arteries become narrowed by fat deposits, platelets often clump together. This further narrows the arteries and increases the chance of heart attack, stroke, or other circulation problems. Plavix reduces the risk of these events by preventing platelets from forming into clumps.

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Clopidogrel

Clopidogrel bisulfate is an inhibitor of A.P. induced platelet aggregation acting by direct inhibition of adenosine diphosphate (ADP) binding to its receptor and of the subsequent A.P. mediated activation of the glycoprotein GPIIb/ IIIa complex. Clopidogrel bisulfate is a white to off-white powder. It is practically insoluble in water at neutral pH but freely soluble at pH 1. It also dissolves freely in methanol, dissolves sparingly in methylene chloride, and is practically insoluble in ethyl ether. It has a specific optical rotation of about +56°. C;p[odpgre; for oral administration is provided as pink, round, biconvex, engraved film-coated tablets containing 97.875 mg of clopidogrel bisulfate which is the molar equivalent of 75 mg of clopidogrel base.

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The recommended adult dose of clopidogrel is 75 mg once daily with or without food. When used by people with acute coronary syndromes, a 300 mg "loading dose" is initially prescribed. After this, treatment starts with 75 mg once daily.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important that this medication be taken exactly as prescribed by the doctor. If you miss a dose, take it as soon as you remember it. If it is almost time for your next dose, skip the missed dose and resume your dosing schedule. Do not double up the dose.

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Plavix Side Effects

Plavix (clopidogrel) is usually very well tolerated. The most common side effects of Plavix were:

  • abdominal or stomach pain (mild)
  • aching muscles
  • back pain
  • dizziness
  • general feeling of discomfort or illness
  • headache
  • heartburn
  • anxiety
  • constipation
  • depression
  • diarrhea
  • itching
  • leg cramps
  • numbness or tingling
  • nausea
  • skin rash
  • trouble sleeping
  • unusual tiredness
  • vomiting
  • weakness

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Plavix Precautions

Clopidogrel should not be taken by anyone who:

  • is sensitive or allergic to clopidogrel or any ingredient of the medication
  • has an active bleeding condition such as a bleeding stomach ulcer or a brain hemorrhage
  • has significant liver disease or cholestatic jaundice

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Plavix Manufacturer

No information is available about the manufacturer of Plavix at this time.

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