Fosamax

Fosamax (alendronate) belongs to a family of medications known as bisphosphonates. Fosamax is prescribed for the treatment and prevention of osteoporosis in postmenopausal women. Fosamax is also used for the treatment of osteoporosis in men. As well, Fosamax may be used to treat and prevent steroid-induced osteoporosis in men and women. This type of osteoporosis occurs when a patient is required to take corticosteroids such as prednisone for long periods of time. Fosamax (alendronate) may also be used to treat Paget's disease of the bone for both men and women. Fosamax works by increaseing the density of bones, making them less likely to break.

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Alendronate

Alendronate sodium is a bisphosphonate that acts as a specific inhibitro of osteoclast-mediated bone resorption. Bisphosphonates are synthetic analogs of pyrophosphate that bind to the hydroxypatite found in bone. Alendronate is a white, crystalline, nonhygroscopic powder. It is soluble in water, very slightly soluble in alcohol, and practically insoluble in chloroform. Tablets of Fosamax (alendronate) for oral administration contain 6.53, 13.05, 45.68, 52.21, or 91.37 mg of alendronate monosodium salt trihydrate, which is the the molar equivalent of 5, 10, 35, 40, and 70 mg.

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Canadian Fosamax

Fosamax is available in strengths of 5 mg, 10 mg, 40 mg, and 70 mg.

5 mg: Each white, round, uncoated tablet, with an outline of a bone image on one side and "MRK 925" on the other, contains alendronate 5 mg as alendronate sodium. Nonmedicinal ingredients: anhydrous lactose, croscarmellose sodium, magnesium stearate, and microcrystalline cellulose.

10 mg: Each white, oval, wax-polished tablet, with "MRK" engraved on one side and "936" on the other, contains alendronate 10 mg as alendronate sodium. Nonmedicinal ingredients: anhydrous lactose, carnauba wax, croscarmellose sodium, magnesium stearate, and microcrystalline cellulose.

40 mg: Each white, triangle-shaped, uncoated tablet, with "FOSAMAX" on one side and "MRK 212" on the other, contains alendronate 40 mg as alendronate sodium. Nonmedicinal ingredients: anhydrous lactose, croscarmellose sodium, magnesium stearate, and microcrystalline cellulose.

70 mg: Each white, oval, uncoated tablet, with an outline of a bone image on one side and "31" on the other, contains 70 mg alendronate as alendronate sodium. Nonmedicinal ingredients: anhydrous lactose, croscarmellose sodium, magnesium stearate, and microcrystalline cellulose.

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Fosamax Side Effects

Fosamax (alendronate) is usually very well tolerated. The most common side effects of Fosamax were:

  • constipation
  • diarrhea
  • full or bloated feeling
  • gas
  • headache
  • nausea

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Fosamax Precautions

Alendronate should not be used by anyone who:

  • has an abnormality of the esophagus (passage leading from throat to stomach) that delays the emptying of the esophagus into the stomach
  • cannot stand or sit upright for at least 30 minutes
  • is allergic to any ingredient of this product
  • has low blood calcium
  • has reduced kidney function (creatinine clearance less than 35 mL/minute)

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Fosamax Manufacturer

No information is available about the manufacturer of Fosamax at this time.

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