Casodex (bicalutamide)
Casodex (bicalutamide) belongs to a group of medicines known as nonsteroidal antiandrogens. Another nonsteroidal antiandrogen is flutamide. Nonsteroidal antiandrogens such as bicalutamide block the effect of the male hormone testosterone in the body. Casodex (bicalutamide) is used in combination with another treatment that reduces the amount of testosterone in the body (e.g., goserelin ) for the treatment of prostate cancer. Your doctor may choose to use Casodex for other conditions not listed here. If you're unsure why you are taking this medication, please ask your doctor.
Bicalutamide
bicalutamide is a non-steroidal antiandrogen. Bicalutamide competitively inhibits the action of androgens by binding to cytosol androgen receptors in the target tissue. Prostatic carcinoma is known to be androgen sensitive and responds to treatment that counteracts the ffect of androgen and/or removes the source of androgen.
When bicalutamide is combined with luteinizing hormone-releasing hormone (LHRH) analogue therapy, the suppression of serum testosterone induced by the LHRH analogue is not affected. However, in clinical trials with bicalutamide as a single agent for prostate cancer, rises in serum testosterone and estradiol have been noted.
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Canadian Casodex
Casodex is available as white film-coated tablets containing bicalutamide 50 mg. Nonmedicinal ingredients include lactose, magnesium stearate, methylhydroxypropylcellulose, polyethylene glycol, polyvidone, sodium starch glycolate, and titanium dioxide. Casodex does not contain yeast or gluten.
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Casodex Side Effects
Casodex (bicalutamide) is usually very well tolerated. The most common side effects of Casodex were:
- back pain
- constipation
- decrease in appetite
- diarrhea
- dizziness
- headache
- hot flashes
- impotence or reduction in sexual desire
- nausea
- sleeping problems
- swelling of breasts with pain or tenderness
- bloated feeling
- confusion
- drowsiness
- dry mouth
- flu-like symptoms (headache, muscle or joint pain, tiredness)
- nervousness
- vomiting
Casodex Precautions
This medication should not be used by:
- anyone sensitive or allergic to bicalutamide or ingredients of the tablet
- children
- females
Casodex Manufacturer
Casodex is a registered trademark of AstraZeneca
