Bextra (valdecoxib)
Bextra (valdecoxib) is indicated for the signs and symptoms of osteoarthritis and adult rheumatoid arthritis as well as for the treatment of primary dysmenorrhea. Bextra works by blocking the action of COX-2, and enzyme involved in pain and inflammation. Bextra is different from other NSAIDs because it blocks the COX-2 enzyme and does not target the COX-1 enzyme, which ibuprofen and naproxen do. COX-1 helps to protect the stomach and provides other useful benefits to the body. One bextra dose is often enough for a full 24 hours of pain and discomfort relief.
Valdecoxib
The active ingredient in Bextra is valdecoxib sodium (valdecoxib). Valdecoxib is a substituted benzimidazole that inhibits gastric acid secretion. The color of valdecoxib is white and may have a slight yellowish tinge. Valdecoxib is very soluble in water and methanol, and insoluble in ether and n-hexane. Its stability is a function of the environmental acidity; valdecoxib degrades rapidly in acid, and is more stable under alkaline situations.
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Canadian Bextra
Bextra Tablets for oral administration contain either 10 mg or 20 mg of valdecoxib. Inactive ingredients include lactose monohydrate, microcrystalline cellulose, pregelatinized starch, croscarmellose sodium, magnesium stearate, hydroxypropyl methylcellulose, polyethylene glycol, polysorbate 80, and titanium dioxide.
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Bextra Side Effects
Bextra (valdecoxib) is usually very well tolerated. The most common side effect that may be associated with Bextra are:
- Hypertension
- Back pain
- Flu-like symptoms
- Accidental Injury
- Dizziness
- headache
- Abdominal pain or fullness
- Diarrhea
- Dyspepsia
- Flatulence
- Nausea
- Myalgia
- Sinusitis
- Upper respiratory infection
- Skin rash
Bextra Precautions
Bextra can cause GI discomfort and, rarely, more serious GI side effects, which may result in hospitalization and even fatal outcomes. Although serious GI tract ulcerations and bleeding can occur without warning symptoms, patients should be alert for the signs and symptoms of ulcerations and bleeding, and should ask for medical advice when observing any indicative sign or symptoms. Patients should be apprised of the importance of this follow-up Patients should report to their physicians, signs or symptoms of gastrointestinal ulceration or bleeding, skin rash, weight gain, or edema.
Bextra Manufacturer
Bextra is a registered trademark of Pfizer Inc.
