Avandia (rosiglitazone)
Avandia (rosiglitazone) is used to treat a certain type of diabetes mellitus (type 2 diabetes , formerly known as non-insulin dependent diabetes). Avandia reduces levels of blood glucose by helping insulin to work more effectively and allowing the cells of the body to take glucose in more easily. By controlling blood glucose levels effectively and making cells more "sensitive" to insulin, Avandia (rosiglitazone) can help prevent or delay the long and short-term complications of diabetes (e.g., kidney disease, eye problems, nerve problems). This drug can be used alone or together with other agents used to treat diabetes (e.g., glyburide, metformin, insulin).
Rosiglitazone
Rosiglitazone, a member of the thiazolidinedione class of antidiabetic agents, improves glycemic control by improving insulin sensitivity. Rosiglitazone is a highly selective and potent agonist for the peroxisome proliferator-activated receptor-gamma (PPAR). In humans, PPAR receptors are found in key target tissues for insulin action such as adipose tissue, skeletal muscle, and liver. Activation of PPAR-nuclear receptors regulates the transcription of insulin-responsive genes involved in the control of glucose production, transport, and utilization. In addition, PPAR-responsive genes also participate in the regulation of fatty acid metabolism.
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Canadian Avandia
Avandia is available in strengths of 2 mg, 4 mg, and 8 mg.
2 mg: Each pink, pentagonal, film-coated tablet, marked "SB" on one side and "2" on the other, contains rosiglitazone 2 mg.
4 mg: Each orange, pentagonal, film-coated tablet, marked "SB" on one side and "4" on the other, contains rosiglitazone 4 mg.
8 mg: Each red-brown, pentagonal, film-coated tablet, marked "SB" on one side and "8" on the other, contains rosiglitazone 8 mg.
Nonmedicinal ingredients: hydroxypropyl methylcellulose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene glycol, sodium starch glycolate, titanium dioxide, and triacetin; colourant: one or more of the following: synthetic red and yellow iron oxides and talc.
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Avandia Side Effects
Avandia (rosiglitazone) is usually very well tolerated. The most common side effects of Avandia were:
- Upper respiratory tract infection
- Injury
- Headache
- Back pain
- Hyperglycemia
- Fatigue
- Sinusitis
- Diarrhea
- Hypoglycemia
Avandia Precautions
Avandia, like other thiazolidinediones, alone or in combination with other antidiabetic agents, can cause fluid retention, which may exacerbate or lead to heart failure. Patients should be observed for signs and symptoms of heart failure. In combination with insulin, thiazolidinediones may also increase the risk of other cardiovascular adverse events. AVANDIA should be discontinued if any deterioration in cardiac status occurs.
Avandia Manufacturer
Avandia is a registered trademark of GlaxoSmithKline
