Product InformationAclasta Injection (Zoledronic Acid) acid belongs to the family of medications known as bisphosphonates. Aclasta Injection (Zoledronic Acid) is used for the treatment of Paget's disease of the bone. Normally, the body maintains a balance between the processes of breaking down and building up bone. In Paget's disease, this balance becomes disturbed so that too much bone is being broken down. Aclasta Injection (Zoledronic Acid) works by restoring balance to the bone breakdown and buildup process.
Your doctor may have suggested Aclasta Injection (Zoledronic Acid) for conditions other than the ones listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Aclasta (Zoledronic Acid), speak to your doctor. Do not stop taking Aclasta Injection (Zoledronic Acid) without consulting your doctor.
Aclasta Injection (Zoledronic Acid) is available as a solution for intravenous (into a vein) injection in a strength of 5 mg.
Each 100 mL bottle of Aclasta contains 5 mg of zoledronic acid. Nonmedicinal ingredients: mannitol, sodium citrate, and water for injection.
Aclasta Injection (Zoledronic Acid) should not be used by anyone who:
is allergic to zoledronic acid or any ingredient of this product
has low blood calcium levels that have not been corrected
The following Aclasta side effects have been reported with a frequency at least 1% by people taking Aclasta Injection (Zoledronic Acid). Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects of Aclasta.
bone, muscle, or joint pain
fever and chills
flu-like symptoms (fever, chills, bone pain, or muscle and joint pain)
Although most of the following more serious Aclasta side effects are rare, check with your doctor as soon as possible if they occur:
eye pain, redness, or inflammation
shortness of breath
signs of low blood calcium levels (muscle spasms, tingling or numbness of the fingers and mouth, twitching, or memory loss)
Although most of the following serious Aclasta side effects are rare, stop taking Aclasta Injection (Zoledronic Acid) and seek medical attention immediately if they occur:
signs of a severe allergic reaction (hives; difficulty breathing; swelling of the mouth, lips, tongue, or throat)
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.
Health Canada recently approved Aclasta Injection (Zoledronic Acid) for the treatment of patients having Paget's disease of bone.
Worsening of kidney function, which may progress to kidney failure, has been reported with drugs of the bisphosphonates class which Aclasta is part of. Therefore, your doctor will measure your kidney function before your treatment with Aclasta. The use of Aclasta is not recommended in patients with severe impairment in kidney function. Also, the duration of the infusion should be no less than 15 minutes.
If you have had a serious or unexpected reaction to Zometa or Aclasta you may notify either Novartis Pharmaceuticals Canada Inc. or Health Canada as follows:
Novartis Pharmaceuticals Canada Inc.
385 Bouchard Blvd.
Dorval, (QC) H9S 1A9
Tel: 866 234-2345
Fax: 866 678-6789